Six Nations: Billy Vunipola on England bench for Calcutta Cup match
"I feel honoured and humbled to be part of such a historic occasion. I treasure the experience."
"It's the oldest international fixture and it means a lot to both countries," said head coach Eddie Jones.
The backline shows three changes, with scrum-half Ben Youngs, centre Jonathan Joseph and wing Jack Nowell returning.
The number eight made his comeback from a knee injury last weekend but Nathan Hughes will continue in the position in an unchanged England pack.
Loose-head prop Joe Marler will lead the team out on his 50th cap - with Billy's brother Mako Vunipola also starting on the bench having himself recently returned from injury - while fit-again wing Anthony Watson also returns to the matchday squad.
"I congratulate Joe," Jones added. "I've coached a lot of good players and he is certainly one of the best. He is an honest and committed team man and a fine individual."
A victory for England on Saturday would give the defending Grand Slam champions a record-equalling 18th consecutive win.
"We're focused on ourselves," said Jones. "We want to give our fans a really good performance.
"We've worked hard in this Six Nations and feels like a good performance is just around the corner."
Scotland will announce their team at 12:30 GMT.
Billy Vunipola has been named on the bench for England's Calcutta Cup meeting with Scotland on Saturday.